Division of Biological Sciences

Phage Genomics Research Initiative

The Phage Genomics Research Initiative is an exciting and innovative opportunity for freshmen biology majors entering UC San Diego in fall 2009 to acquire hands-on research experience.

Students accepted into the Phage Genomics Research program will learn how to approach research problems creatively. Research will focus on bacteriophage, rapidly evolving viruses that infect bacteria. Students will isolate new bacteriophage from the environment and sequence and characterize their genomes. A goal is for the results to be published in scientific journals with the students listed as co-authors.

Selected students who participate in the program for all 3 quarters will earn the equivalent of 1 laboratory course and 1 biology elective course toward their degree.

UC San Diego is one of only 12 universities nationwide selected by the Howard Hughes Medical Institute (HHMI) to offer this program to our students through HHMI's Science Education Alliance (SEA).

Take a look at the following link to watch a fantastic video about the first year of the phage course, in which UC San Diego student Hannah Wang plays an eloquent role.

Apply here  (Application is now Closed)


Lead Instructors: Kit and Joe Pogliano

We've been seeking ways to engage more of our students in research and inquiry-directed learning experiences. This sort of experiment -- having a group of students doing research overthecourse of an academic year in a formalized lab course -- is something we've dreamed ofdoing for years. -- Kit Pogliano, Ph.D., UC San Diego, Biological Sciences

 


Course Descriptions

There are four courses associated with the Phage Genomics Research Initiative:
BIMM 171 is scheduled for TBA
BIMM 171A is scheduled for TBA

BIMM 171 (Genomics Research Initiative) This class will examine the theoretical and practical basis of modern genomics research. Students will learn the theoretical basis of genomics and tools used for the sequencing and annotation of genomic DNA, and computational and molecular methods for the study of evolution.

BIMM 171A (Genomics Research Initiative Laboratory I) Students will isolate bacterial viruses or other organisms from the environment and characterize them by methods including electron microscopy and nucleic acid analysis.  The genomic DNA will be purified, and sent for sequencing.

BIMM 171B (Genomics Research Initiative Laboratory II) Students will characterize the genomic sequence of the organisms isolated in BIMM171A and use molecular and computational tools to resolve ambiguities and close gaps. They will then annotate the DNA sequence to identify protein and RNA coding regions.

BIMM 171C (Genomics Research Initiative Laboratory III) Computational methods will be used to characterize the annotated genome sequence produced in BIMM 171A-B to study the evolution of genes and their products.  Various mechanisms shaping genome evolution will be discussed and the genome evaluated for evidence of these processes.

Read more about this innovative undergraduate research program at:
Our First Initiative / HHMI - SEA and at: UC San Diego Selected for Nationwide Science Education Program

Learn more about phage genomics:

Gene Weavers


Scientific Inquiry