Publications

Elpek KG, Rubinstein MP, Bellemare-Pelletier A, Goldrath AW, Turley SJ. Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes. [Full Text] [PDF]

Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, Coussens  LM, Karin M, Goldrath AW, Johnson RS. Macrophage expression of hypoxia-inducible  factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer  Res.

2010 Oct 1;70(19):7465-75. [Full Text] [PDF]

D'Cruz LM, Yang CY, Goldrath AW. Transcriptional regulation of NKT cell development and homeostasis. Curr Opin Immunol. 2010 Apr;22(2):199-205. [Full Text] [PDF]

D'Cruz LM, Knell J, Fujimoto JK, Goldrath AW. An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells. Nat Immunol. 2010 Mar;11(3):240-9. [Full Text] [PDF]

Monticelli LA, Yang Y, Knell J, D'Cruz LM, Cannarile MA, Engel I, Kronenberg M, Goldrath AW. Transcriptional regulator Id2 controls survival of hepatic NKT cells. Proc Natl Acad Sci U S A. 2009 Nov 7;106(46):19461-6. [Full Text] [PDF]

Cheung KP, Yang E, Goldrath AW. Memory-like CD8+ T cells generated during homeostatic proliferation defer to antigen-experienced memory cells. J Immunol. 2009 Sep 1;183(5):3364-72. [Full Text] [PDF]

D'Cruz LM, Rubinstein MP, Goldrath AW. Surviving the crash: transitioning from effector to memory CD8+ T cell. Semin Immunol. 2009 Apr;21(2):92-8. Epub 2009 Mar 6. Review. [Full Text] [PDF]

Heng TS, Painter MW; Immunological Genome Project Consortium. The Immunological Genome Project: networks of gene expression in immune cells. Nat Immunol. 2008 Oct;9(10):1091-4. [Full Text] [PDF]

Rubinstein MP, Lind NA, Purton JF, Filippou P, Best JA, McGhee PA, Surh CD, Goldrath AW. IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. Blood. 2008 Nov 1;112(9):3704-12. [Full Text] [PDF]

Park KW, Waki H, Villanueva CJ, Monticelli LA, Hong C, Kang S, MacDougald OA, Goldrath AW, Tontonoz P. Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation. Mol Endocrinol. 2008 Sep;22(9):2038-48. [Full Text] [PDF]

Epardaud M, Elpek KG, Rubinstein MP, Yonekura AR, Bellemare-Pelletier A, Bronson R, Hamerman JA, Goldrath AW, Turley SJ. Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells. Cancer Res. 2008 Apr 15;68(8):2972-83. [Full Text] [PDF]

Proc Natl Acad Sci USA. 2010 Dec 14;107(50):21647-52. Epub 2010 Nov 22. [Full Text] [PDF]

Cannarile MA, Lind NA, Rivera R, Sheridan AD, Camfield KA, Wu BB, Cheung KP, Ding Z, Goldrath AW. Transcriptional regulator Id2 mediates CD8+ T cell immunity. Nat Immunol. 2006 Dec;7(12):1317-25. [Full Text] [PDF]

Goldrath AW, Hedrick SM. Central tolerance matters. Immunity. 2005 Aug;23(2):113-4. Review. [Full Text] [PDF]

Goldrath AW, Luckey CJ, Park R, Benoist C, Mathis D. The molecular program induced in T cells undergoing homeostatic proliferation. Proc Natl Acad Sci USA 2004 Nov 30; 101(48):16885-90. [Full Text] [PDF]

Goldrath AW, Sivakumar PV, Glaccum M, Kennedy MK, Bevan, MJ, Benoist C, Mathis D, Butz EA. Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med. 2002 Jun 17;195(12):1515-22. [Full Text] [PDF]

Goldrath AW. Maintaining the status quo: T-cell homeostasis. Microbes Infect. 2002 Apr;4(5):539-45. Review. [Full Text] [PDF]

Goldrath AW, Bogatzki LY, Bevan MJ. Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J Exp Med. 2000 Aug 21;192(4):557-64. [Full Text] [PDF]

Bevan MJ, Goldrath AW. T-cell memory: You must remember this ... Curr Biol. 2000 May 4;10(9):R338-40. Review. [Full Text] [PDF]

Goldrath AW, Bevan MJ. Selecting and maintaining a diverse T-cell repertoire. Nature. 1999 Nov 18;402(6759):255-62. Review. [Full Text] [PDF]

Goldrath AW, Bevan MJ. Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity. 1999 Aug;11(2):183-90. [Full Text] [PDF]

Goldrath AW, Hogquist KA, Bevan MJ. CD8 lineage commitment in the absence of CD8. Immunity. 1997 May;6(5):633-42. [Full text] [PDF]