THE HALPAIN LAB
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THE HALPAIN LAB |
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Publications Dehmelt L, Halpain S. (2007) Neurite outgrowth: a flick of the wrist. Curr Biol. 17(15):R611-4.
Calabrese B, Shaked GM, Tabarean IV, Braga J, Koo EH, Halpain S. (2007) Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein. Mol Cell Neurosci. 35(2):183-93.
Al-Bassam J, Roger B, Halpain S, Milligan RA. (2007) Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c. Cell Motil Cytoskeleton. 64(5):377-89.
Halpain S. (2006) They're plastic, but they recycle. Neuron 52(5):746-8.
Dehmelt L, Nalbant P, Steffen W, Halpain S. (2006) A microtubule-based, dynein-dependent force induces local cell protrusions: Implications for neurite initiation. Brain Cell Biol. 35(1):39-56.
Calabrese B, Wilson MS, Halpain S. (2006) Development and regulation of dendritic spine synapses. Physiology (Bethesda). 21:38-47. Review.
Halpain S, Dehmelt L. (2006) The MAP1 family of microtubule-associated proteins. Genome Biol. 7(6):224. Review.
Calabrese B., Halpain S. (2005) Essential Role for the PKC Target MARCKS in Maintaining Dendritic Spine Morphology. Neuron 48:77.
Halpain S., Spencer K., Graber S. (2005) Dynamics and pathology of dendritic spines. Prog Brain Res. 147:29.
Dehmelt L., Halpain S. (2005) The MAP2/Tau family of microtubule-associated proteins. Genome Biol. 6:204.
Graber S., Maiti S., Halpain S. (2004) Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spines. Neuropharmacology 47:706-13.
Roger B., Al-Bassam J., Dehmelt L., Milligan R.A., Halpain S. (2004)MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain. Curr Biol. 14:363-71.
Dehmelt L., Halpain S. (2004) Actin and Microtubules in Neurite Initiation: Are MAPs the Missing Link? J. Neurobiology 58:18-33. Review.
Dehmelt L., Smart F.M., Ozer R.S. and Halpain S. (2003) The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation. J.
Neuroscience 23:9479-90. Halpain S. (2003) Actin in a supporting role. Nat Neurosci. 6:101-2. Review.
Malmendal A., Halpain S., Chazin WJ. (2003) Nascent structure in the kinase anchoring domain of microtubule-associated protein 2. Biochem Biophys Res Commun. 301:136-42.
Halpain S. (2002) Making new connections. Trends Cell Biol. 12:455-7.
Al-Bassam J., Ozer R.S., Safer D., Halpain S., Milligan RA. (2002) MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments.
J Cell Biol. 157:1187-96.
Halpain S. (2000) Actin and the agile spine: how and why do dendritic spines dance? Trends Neurosci. 23:141-6. Review
Lim R.W., Halpain S. (2000) Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein. J Biol Chem. 275:20578-87.
Ozer R.S., Halpain S. (2000) Phosphorylation-dependent localization of microtubule-associated protein MAP2c to the actin cytoskeleton. Mol Biol Cell. 11:3573-87.
Smart F.M., Halpain S. (2000) Regulation of dendritic spine stability. Hippocampus 10:542-54. Review. Norris, C.M., Halpain, S., and Foster, T.C. (1998) Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca 2++ channels. J. Neuroscience 18: 3171-3179.
Norris, C.M., Halpain, S., and Foster, T.C. (1998) Alterations in the balance of protein kinase/phosphatase acitvities parallel reduced synaptic strength during aging. J. Neurophysiol. 80: 1567-1570.
Halpain, S., Hipolito, A., and Saffer, L. (1998) Regulation of F-actin stability in dendritic spines by glutamate receptors and calcineurin.J. Neuroscience 18: 9835-9844.
Philpot, B.D., Lim, J.H., Halpain, S., and Brunges, P.C. (1997) Experience-dependent modifications in MAP2 phoshorylation in rat olfactory bulb. J. Neuroscience 17:9596-9604.
Plautz, J.D., Day, R.N., Dailey, G., Welsh, S.B., Hall, J.C., Halpain, S., and Kay, S.A. (1996) Green fluorescent protein and its derivatives as versatile markers for gene expression
in living Drosophila melanogaster, plant, and mammalian cells. Gene173: 83-87.
Burack, M.A and Halpain, S. (1996) Site-specific regulation of Alzheimer-like tau phosphorylation in living neurons.Neuroscience
72: 167-184. Halpain, S. (1996) Analysis of protein dephosphorylation in intact cells and extracts, Neuronmethods Vol. 30: Hemmings, ed., Regulatory Protein Modification: Techniques and Protocols, Humana Press, Inc., pp. 45-65.
Gamblin, T.C., Nachmanoff, K., Halpain, S., and Williams, R.C. (1996) Recombinant microtubule-associated protein 2c has a stabilizing effect on the dynamic instability of individual microtubules. Biochemistry 35: 12576-12586.
Quinlan, E.M. and Halpain, S. (1996) Emergence of acitivity-dependent, bidirectional control of MAP2 phosphorylation during postnatal development. J. Neuroscience 16: 7627-7637.
Halpain, S. and Girault, J.-A (1995) The use of brain slices to study protein phosphatase regulation and function.Neuroprotocols: A Companion to Methods in Neuroscience 6: 46-55.
Freeman, M.A. and Halpain, S. (1995) Modulation of Alzheimer's-like tau phosphorylation in neonatal rat forebrain by phosphatase inhibitors and basic fibroblast growth factor. Proceeding of the Fourth International Conference on Alzheimer's Disease and Related Disorders, K. Iqbal, ed., John Wiley and Sons, pp. 533-541.
Halpain, S. and Greengard, P. (1991) Protein dephosphorylation as a mediator of NMDA receptor signal transduction. In: Excitatory Amino Acids and Second Messenger System, V.I. Teichberg and L. Turshi(eds.), Springer-Verlag, Berlin p. 121-142.
Halpain, S. and Greengard, P. (1990) Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2. Neuron 5: 237-246. |
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Shelley
Halpain, Ph.D. |