Selected Publications

  1. Michael, T.P., Mockler, T.C., Breton, G., McEntee, C., Byer, A., Trout, J.D., Hazen, S.P., Shen, R., Priest, H.D., Sullivan, C.M., Givan, S.A., M. Yanovsky, Hong, F., Kay, S.A., Chory, J. (2008) Network discovery pipeline elucidates conserved time-of-day-specific cis-regulatory modules. PLoS Genetics in press

  2. Para, A., Farré, E., Imaizumi, T., Pruneda-Paz, J.L., Harmon, F.G., Kay, S.A. (2007) PRR3 Is a Vascular Regulator of TOC1 Stability in the Arabidopsis Circadian Clock. Plant Cell 11:3462-73.

  3. Imaizumi, T., Kay, S.A., Schroeder, J.I. (2007) Circadian rhythms: Daily watch on metabolism. Science 318:1730-1.

  4. Sawa, M., Nusinow, D.A., Kay, S.A., Imaizumi, T. (2007) FKF1 and GIGANTEA complex is required for day-length measurement in Arabidopsis. Science 318:261-5.

  5. Farré, E.M., Kay, S.A. (2007) PPR7 protein is regulated by diurnal and circadian mechanisms in Arabidopsis. The Plant J 52:548-60.

  6. Liu, A.C., Lewis, W.G., Kay, S.A. (2007) Mammalian circadian signaling networks and therapeutic targets. Nat Chem Biol. 3:630-639.

  7. Breton, G., Kay, S.A. (2007) Plant biology: Time for growth. Nature 448:265-266.

  8. Borevitz, J.O., Hazen, S.P., Michael, T.P., Morris, G.P., Baxter, I.R., Hu, T.T., Chen, H., Werner, J.D., Norborg, M., Salt, D.E., Kay, S.A., Chory, J., Weigel, D., Jones, J.D., Ecker, J.R. (2007) Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana. Proc. Natl. Acad. Sci., USA 104:12057-12062.

  9. Imaizumi, T., Schroeder, J.I., Kay, S.A. (2007) In SYNC: The ins and outs of circadian oscillations in calcium. Sci STKE 390:32.

  10. Fernandez, M.P., Chu, J., Villella, A., Atkinson, N., Kay, S.A., Ceriani, M.F. (2007) Imparied clock output by altered connectivity in the circadian network. Proc. Natl. Acad. Sci, 104:5650-5.

  11. Liu, A., Welsh, D.K., Ko, C., Tran, H., Zhang, E., Priest, A., Burr, E., Singer, O., Meeker, K., Verma, I., Doyle, F., Takahashi, J., and Kay, S.A. (2007) Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell 129:605-16.

  12. Zeilinger, M.N., Farre, E.M., Taylor, S.R., Kay, S.A., Doyle III, F.J. (2006) A novel computational model of the circadian clock in Arabidopsis that incorporates PRR7 and PRR9. Molecular Systems 2:58-71

  13. Sato, T.K., Yamada, R.G., Ukai, H., Baggs, J.F., Miragila, L.J., Kobayashi, T.J., Welsh, D.K., Kay, S.A., Ueda, H.R., Hogenesch, J.B. (2006) Feedback repression is required for mammalian circadian clock function. Nature Genetics 38:312-9.

  14. Hazen, S.P., Schultz, T.F., Pruneda-Paz, J.L., Borevitz, J.O., Ecker, J.R. and Kay, S.A. (2005) LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms. Proc. Natl. Acad. Sci., USA 102:10387-10392.

  15. Imaizumi, T., Schultz, T.S., Harmon, F.G., Ho, L.A., Kay, S.A.* (2005) FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis. Science 309:293-297.

  16. Welsh, D.K., Imaizumi, T., Kay, S.A. (2005) Real-time reporting of circadian-regulated gene expression by luciferase imaging in plants and Mammalian cells. Methods in Enzymol 393:269-88.

  17. Welsh, D.K., Yoo, S.H., Liu, A.C., Takahashi, J.A., Kay, S.A. (2004) Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression. Curr. Biol. 14 (24):2289-2295.

  18. Sato, T.K., Panda, S., Miraglia, L.J., Reyes, T.M., Rudic, R.D., McNamara, P., Naik, K.A., FitzGerald, G.A., Kay, S.A., Hogenesch, J.B. (2004) A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 43:527-537. 120. Ueda, H.R., Hayashi, S., Matsuyama, S., Yomo, T., Hashimoto, S., Kay, S.A., Hogenesch, J.B., Lino, M. (2004) Universality and flexibility in gene expression from bacteria to human. Proc. Natl.

    19. Acad. Sci., USA 101:3765-3769.

  19. Mas, P., Kim, W-Y., Somers, D., Kay, S.A. (2003) Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis. Nature 426:567-570.

  20. Imaizumi, T., Tran, H.G., Swartz, T.E., Briggs, W.R., Kay, S.A. (2003) FKF1 is critical for photoperiodic-specific light signaling in Arabidopsis. Nature 426:302-6

  21. Hazen, S.P. and Kay, S.A. (2003) Gene arrays are not just for measuring gene expression. Trends in Plant Science 8:413-416.

  22. Panda, S., Provencio, I., Tu, D.C., Pires, S.S., Rollag, M.D., Castrucci, A.M., Pletcher, M., Sato, T.K., Wiltshire, T., Andahazy, M., Kay, S.A., Van Gelder, R.N., Hogenesch, J.B. (2003) Melanopsin is required for non-image forming photic responses in blind mice. Science 301:525- 527.

  23. Schultz, T.F., Kay, S.A. (2003) Circadian clocks in daily and seasonal control of development. Science 301:326-328.

  24. Yanovsky, M.J. and Kay, S.A. (2003) Living by the calendar: How plants know when to flower. Nature Review Molecular Cellular Biology 4:265-275.

  25. Wiltshire, T., Pletcher, M.T., Batalov, S., Barnes, S.W., Tarantino, L.M., Cooke, M.P., Wu, H., Smylie K., Santrosyan, A., Copeland, N.G., Jenkins, N.A., Kalush, F., Mural, R.J., Glynne, R.J., Kay, S.A., Adams, M.D., Fletcher, C.F.(2003) Genome- wide single-nucleotide polymorphism analysis defines haplotype patterns In mouse. PNAS U.S.A. 100:3380-3385.

  26. Panda, S., Sato, T.K., Castrucci, A.M., Rollag, M.D., DeGrip, W.J., Hogenesch, J.B., Provencio, I., and Kay, S.A. (2003) Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science 298:2213-2216.

  27. Ceriani, M.F., Hogenesch, J.B., Yanovsky, M., Villella, A., Panda, S., Straume, M., and Kay, S.A. (2002) Genome-wide expression analysis in Drosophila predicts genes controlling circadian behavior. J. Neuroscience 22 9305-9319.

  28. Yanovsky, M.J. and Kay, S.A. (2002) Molecular basis of seasonal time measurement in

    29. Arabidopsis. Nature 419:308-312.

  29. Panda, S., Hogenesch, J.B., Kay, S.A. (2002) Circadian rhythms from flies to human. Nature 417:329-335.

  30. Panda, S., Antoch, M.P., Miller, B.H., Su, A.I., Schook, A.B., Straume, M., Schultz, P.G., Kay, S.A., Takahashi, J.S. and Hogenesch, J.B. (2002) Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109:307-320.

  31. Alabadi, D., Yanovsky, M.J., Mas, P., Harmer, S.L., and Kay, S.A. (2002) Critical role for CCA1 and LHY in maintaining circadian rhythmicity in Arabidopsis. Curr. Biol. 12:757-761.

  32. Young, M.W. and Kay, S.A. (2001) Time zones: a comparative genetics of circadian clocks. Nat Rev Genet. 2:702-715.

  33. Alabadi, D., Oyama, T., Yanovsky, M., Harmon, F.G., Mas, P. and Kay, S.A. (2001) Reciprocal regulation between TOC1 and LHY/CCA1 within the Arabidopsis circadian clock. Science 293:880-883.

  34. Nadeau et al. (2000) Sequence Interpretation: Functional Annotation of Mouse Genome Sequences. Science 291:1251-1255.

  35. Harmer S.L., Hogenesch J.B., Straume M., Chang H-S., Zhu T., Wang X., Kreps, J.A. and Kay S.A. (2000) Orchestrated transcription of key pathways in Arabidopsis by the circadian clock. Science 290:2110-2113.

  36. Mas, P., Devlin, P.F., Panda, S. and Kay, S.A. (2000) Functional interaction of phytochrome B and cryptochrome 2. Nature 408:207-211.

  37. Strayer, C., Oyama, T., Schultz, T.F., Raman, R., Somers, D.E., Mas, P., Panda, S., Kreps, J.A. and Kay, S.A. (2000). Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog. Science 289:768-771.

  38. Somers, D.E., Schultz, T.F., Milnamow, M. and Kay, S.A. (2000) ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis. Cell 101:319-329.

  39. Scully, A. and Kay, S.A. (2000) Time flies for Drosophila. Cell 100, 297-300.

  40. Park, D.H., Somers, D.E., Kim, Y.S., Choy, Y.H., Lim, H.K., Soh, M.S., Kim, H.J., Kay,S.A., Nam, H.G. (1999) Control of circadian rhythms and photoperiodic flowering by the Arabidopsis GIGANTEA gene. Science 285:1579-1582.

  41. Ceriani, M.F., Darlington, T.K., Staknis, D., Mas, P., Petti, A.A., Weitz, C.J. and Kay, S.A. (1999) Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science 285:553-556.

  42. Somers D., Devlin P. and Kay S.A. (1998). Phytochromes and cryptochromes in the entrainment of the Arabidopsis circadian clock. Science 282:1488-1490.

  43. Stanewsky, R., Kaneko, M., Emery, P., Beretta, B., Wager-Smith K., Kay, S.A., Rosbash M. and Hall, J.C. (1998). The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell 95:681-692.

  44. Darlington, T., Wager-Smith, K., Ceriani, F., Staknis, D., Gekakis, N., Steeves, T., Weitz, C., Takahashi, J. and Kay, S.A. (1998). Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science 280:1599-1603.

  45. Somers, D., Webb, A. Pearson, M. and Kay, S.A. (1998) The short period mutant, toc1-1, alters

    46. circadian clock regulation of multiple outputs throughout development In Arabidopsis thaliana. Development 125:485-494.

  46. Plautz, J., Kaneko, M., Hall, J. and Kay, S.A. (1997). Independent photoreceptive circadian clocks throughout Drosophila. Science 278:1632-1635.

  47. Kay S.A. (1997). As time PASses: the first mammalian clock gene. Science 276:1093.

  48. Kay S.A. (1997). PAS, present and future: clues to the origins of circadian clocks. Science 274:753- 754.

  49. Plautz, J., Straume, M., Stanewsky, R., Jamison, C., Brandes, C., Dowse, H., Hall, J.C. and Kay, S.A. (1997). Quantitative analysis of Drosophila period gene transcription in living animals. J. Biol. Rhythms 12:204-217.

  50. Hicks, K., Millar, A.J., Carre, I., Somers, D., Straume, M., Meeks-Wagner, R. and Kay, S.A. (1996). Conditional circadian dysfunction of the Arabidopsis early-flowering 3 mutant. Science 274:790- 792.

  51. Brandes, C., Plautz, J.D., Stanewsky, R., Jamison, C., Straume, M., Wood, K., Hall, J.C., Kay, S.A. (1996). Novel features of Drosophila per gene expression revealed by real-time luciferase reporting. Neuron 16:687-692.

  52. Millar, A.J., Straume, M., Chory, J., Chua, H.-H., and Kay, S.A. (1995) Regulation of circadian period by phototransduction pathways in Arabidopsis. Science 267: 1163-1166 (Cover).

  53. Millar, A.J., Carre, I., Strayer, C., Chua, N.-H., and Kay, S.A. (1995) Circadian clock mutants in Arabidopsis identified by luciferase imaging. Science 267:1161-1163 (Cover).