Immo E. Scheffler

Research

My laboratory was closed after 35 years of operation. I continue to have an interest in all aspects of mitochondrial biology, and a second, updated edition of my book MITOCHONDRIA was published recently. Collaborations continue with laboratories at UCSD (Taylor, Perkins), at UC Irvine (Wallace) and Neuzil (Australia).

Scheffler Book Cover

Publications

  • Potluri, P., Procaccio, V., Scheffler, I. E., and Wallace, D. C. (2016). High throughput gene complementation screening permits identification of a mammalian mitochondrial protein synthesis (ρ−) mutant. Biochimica et Biophysica Acta (BBA)-Bioenergetics.
  • Scheffler, I. E. (2015). Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency. Journal of inherited metabolic disease, 38(3), 405-415.
  • Scheffler, I.E. (2008). MITOCHONDRIA. 2nd edition, J. Wiley and Sons, Inc., Hoboken, New Jersey. 462 pages.
  • Yadava, N., Potluri, P., and I.E. Scheffler (2008) Investigations of the potential effects of phosphorylation of the MWFE and ESSS subunits on complex I activity and assembly. The Int. J.of Biochem. and Cell Biol. 40:447 – 460.
  • Scheffler, I.E. (2008) Signaling pathways from mitochondria to cytoplasm and nucleus. In Handbook of Cell Signaling (R.A. Bradshaw and E.A. Dennis, series editors). Part IV: Events in Intracellular Compartments (M. Farquahar and S.Subramani, editors). Elsevier Science. Invited review, in press.
  • Scheffler, I.E. (2008) Basic Molecular Biology of Mitochondrial Replication. Chapter2, in Drug-Induced Mitochondrial Dysfunction. J. Dykens and Y. Will, editors; John Wiley and Sons, Hoboken, NJ.
  • Dong, L.-F., Low, P., Dyason, J.C., Wang, X.-F., Prochazka, L., Witting, P.K., Freeman, R., Swettenham, E., Valis, K., Turanek, J., Spitz, D.R., Domann, F.E., Scheffler, I.E., Ralph, S.J., and J. Neuzil (2008). Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. Oncogene, 28:1-12.
  • Neuzil, J., Dyason, J.C., Freeman, R., Dong, L.-F., Prochazka, L., Wang, X.-F., Scheffler, I., and Ralph, S.J. (2007). Mitocans as anticancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. J. Bioenerg. Biomembr. 39:65-72.
  • Broderick, K.E., Potluri, P., Zhuang, S., Scheffler, I.E., Sharma, V.S., Pilz, R.B., and Boss, G.R. (2006). Cyanide detoxification by the cobalamin precursor cobinamide. Exp. Biology and Medicine, 231:641-49.
  • Sonoda, J.,Laganiere, J., Mehl, I.R., Barish, G.D., Chong, L.W., Li, X., Scheffler, I.E., Mock, D.C. Bataille, A.R., Robert, F., Lee, C.H. Giguere, V., Evans, R.M. (2007) Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev. 21:1909-1920.
  • Potluri,P., Davila,A., Ruiz-Pesini,E., Mishmar,D., O'Hearn,S., Hancock,S., Simon,M., Scheffler,I.E., Wallace,D.C., and Procaccio,V. (2009). A novel NDUFA1 mutation leads to a progressive mitochondrial complex I-specific neurodegenerative disease. Molecular Genetics and Metabolism, in press.