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E. Peter Geiduschek


The central theme of my research has been the enzymology of gene regulation, specifically of transcriptional regulation and its principal focus has been on fundamental mechanisms, approached from a molecular genetic and biochemical perspective. It is now widely appreciated that the transcriptional apparatus of all cells (archaeal, bacterial and eukaryotic) has common evolutionary roots. It follows that transcription-regulatory mechanisms should also share certain broadly similar mechanistic features. In that spirit, my laboratory worked in parallel with bacteria and their viruses, with eukaryotes, and with archaea.

Select Publications

  • Kassavetis, G.A., Soragni, E., Driscoll, R. and Geiduschek, E.P. (2005). Reconfiguring the connectivity of a multiprotein complex: Fusions of yeast TBP with Brf1, and the function of TFIIIB. Proc. Natl. Acad. Sci. U.S.A. 102:15406-15411.
  • Nechaev, S. and Geiduschek, E.P. (2008) Dissection of the bacteriophage T4 late promoter complex. J. Mol. Biol. 379:402-413.
  • Geiduschek, E.P. (2009) Without a license, or Accidents waiting to happen. Annu. Rev. Biochem. 78:1-28.
  • Geiduschek, E.P. (2010) An introduction to transcription and gene regulation. J. Biol. Chem. 285:25885-25892.
  • Wilkinson, S.P., Ouhammouch, M. and Geiduschek, E.P. (2010) Transcriptional activation in the context of repression mediated by archaeal histones. Proc. Natl. Acad. Sci. U.S.A. 107:6777-6781.
  • Geiduschek, E.P. and Kassavetis, G.A. (2010) Transcription of the T4 late genes. Virology J. 7:288.
  • Twist K.-A.F., Campbell, E.A., Deighan, P., Nechaev, S., Jain, V.,Geiduschek, E.P., Hochschild, A., and Darst, S.A. (2011) Crystal structure of the bacteriophage T4 late-transcription co-activator in complex with the beta-subunit flap domain of E.coli RNA polymerase. Proc. Natl. Acad. Sci. U.S.A. 108: in press.


E. Peter Geiduschek received his Ph.D. from Harvard University. He was awarded a Guggenheim Fellowship and has served on the editorial boards of several scientific journals. Dr. Geiduschek is a member of the National Academy of Sciences and the American Academy of Arts and Sciences and is also a fellow of the American Association for the Advancement of Science and the American Academy of Microbiology.

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