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E. Peter Geiduschek

Research

The central theme of my research has been the enzymology of gene regulation, specifically of transcriptional regulation and its principal focus has been on fundamental mechanisms, approached from a molecular genetic and biochemical perspective. It is now widely appreciated that the transcriptional apparatus of all cells (archaeal, bacterial and eukaryotic) has common evolutionary roots. It follows that transcription-regulatory mechanisms should also share certain broadly similar mechanistic features. In that spirit, my laboratory worked in parallel with bacteria and their viruses, with eukaryotes, and with archaea.

Publications

  • Kassavetis, G.A., Soragni, E., Driscoll, R. and Geiduschek, E.P. (2005). Reconfiguring the connectivity of a multiprotein complex: Fusions of yeast TBP with Brf1, and the function of TFIIIB. Proc. Natl. Acad. Sci. U.S.A. 102:15406-15411.
  • Nechaev, S. and Geiduschek, E.P. (2008) Dissection of the bacteriophage T4 late promoter complex. J. Mol. Biol. 379:402-413.
  • Geiduschek, E.P. (2009) Without a license, or Accidents waiting to happen. Annu. Rev. Biochem. 78:1-28.
  • Geiduschek, E.P. (2010) An introduction to transcription and gene regulation. J. Biol. Chem. 285:25885-25892.
  • Wilkinson, S.P., Ouhammouch, M. and Geiduschek, E.P. (2010) Transcriptional activation in the context of repression mediated by archaeal histones. Proc. Natl. Acad. Sci. U.S.A. 107:6777-6781.
  • Geiduschek, E.P. and Kassavetis, G.A. (2010) Transcription of the T4 late genes. Virology J. 7:288.
  • Twist K.-A.F., Campbell, E.A., Deighan, P., Nechaev, S., Jain, V.,Geiduschek, E.P., Hochschild, A., and Darst, S.A. (2011) Crystal structure of the bacteriophage T4 late-transcription co-activator in complex with the beta-subunit flap domain of E.coli RNA polymerase. Proc. Natl. Acad. Sci. U.S.A. 108: in press.

Biography

E. Peter Geiduschek received his Ph.D. from Harvard University. He was awarded a Guggenheim Fellowship and has served on the editorial boards of several scientific journals. Dr. Geiduschek is a member of the National Academy of Sciences and the American Academy of Arts and Sciences and is also a fellow of the American Association for the Advancement of Science and the American Academy of Microbiology.