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Diagram of left panel: Gene-drive is mediated by a guide RNA (gRNA) that cuts at the exact site (scissors) where the gene-drive element (blue box: Cas9 gene; yellow box: gRNA) is inserted into the genome, resulting in full gene-drive element copying. Right panel: The new allelic drive is accomplished by the addition of a second gRNA (blue box) to a gene drive element that preferentially cuts a detrimental allele (scissors), but not the beneficial allele, resulting in beneficial allele copying.

Next-generation Gene Drive Arrives

CRISPR-based ‘allelic drive’ allows genetic editing with selective precision and broad implications

New CRISPR-based gene drives and broader active genetics technologies are revolutionizing the way scientists engineer the transfer of specific traits from one generation to another.

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