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Mutant Gene Found to Fuel Cancer-Promoting Effects of Inflammation

Crosstalk between tumor and immune response boosts human cancers

A human gene called p53, which is commonly known as the "guardian of the genome," is widely known to combat the formation and progression of tumors. Yet, mutant forms of p53 have been linked to more cases of human cancer than any other gene.

Investigating core mechanisms of how cancer cells respond to their surroundings in the human body, biologists at the University of California San Diego have discovered new evidence about mutant p53 that may reshape our understanding of tumor growth and ultimately how we treat cancer.