Postdoctoral Openings

Gene Drive constructs of Drosophila

Position Description

A postdoctoral research associate position is available in the laboratory of Dr. Valentino Gantz in the Section of Cell and Developmental Biology at the University of California San Diego. The research for this position research will focus on developing strategies to control Gene Drive constructs, for their safe development in the laboratory and as remediation strategies for field applications.The appointment will be for one year initially with potential for renewal. Salary will be a minimum of $48,000 according to experience according to standard UCSD guidelines available at http://postdoc.ucsd.edu/appointment-guidelines/index.html

Qualifications

  • A Ph.D. degree in genetics, molecular or developmental biology, or a related discipline
  • Research experience with insects (preferably Drosophila melanogaster)
  • Solid molecular biology and biochemistry skills
  • CRISPR/Cas9 experimental experience
  • Primary publications in peer-reviewed journals demonstrating excellence in at least one of the above areas

Environment & Research

Our lab is located in the heart of UCSD, in the sunny La Jolla, California. We have outstanding infrastructures and are performing cutting-edge research heavily focused on CRISPR/Cas9 system applied to developmental and evolutionary questions as well as Gene Drive technologies. More info @ www.gantzlab.org

Application

Please email vgantz@ucsd.edu a single pdf file with “PostDoc Application - your name” in the subject line containing 1) One-page personal statement outlining your interests, career goals, and why you want this position, 2) Your CV with complete publication list, 3) Names and contacts of three references.

Stem Cell biology and cancer biology

Academic Division:

Biological Sciences

Academic Department/Research Unit:

Molecular Biology

Description:

Postdoctoral positions are available in Dr. Yang Xu's lab at the Division of Biological Sciences of University of California, San Diego (UCSD). Xu lab is interested in cancer biology and stem cell biology.

Successful applicants should:

The successful applicants should have a recent PhD degree with research experience in stem cell biology or cancer biology. The candidate should be highly motivated, responsible, and have published at least one peer-reviewed research paper as the first author.

How to apply:

To apply, please send CV and contact information of three references to Dr. Yang Xu.

Exploring application of gene-drive systems to plants

Academic Division:

Biological Sciences

Academic Department/Research Unit:

Cell and Developmental Biology

Description:

A postdoctoral position is available to explore the application of gene-drive systems to plants as part of a collaborative effort with the labs of Profs. Martin Yanofsky, Mark Estelle, Valentino Gantz and Ethan Bier at the University of California San Diego. Studies will employ state-of-the-art “active genetic” tools based on CRISPR gene-drive systems that the Bier lab has developed (The Dawn of Active Genetics. 2016. Gantz VM, Bier E. Bioessays, 38:50-63) with the goal of generalizing these technologies to plants.

Applicant Requirements:

Familiarity with CRISPR technology and Arabidopsis genetics is advantageous but not essential.

How to apply:

Applicants should send: a cover letter briefly summarizing their background and research goals, a CV with contact information, and the names and contact information of three references to Martin Yanofsky.

Autophagy of lipid droplets in YEAST models

Academic Division:

Biological Sciences

Academic Department/Research Unit:

Molecular Biology

Description:

Applications are invited for a postdoctoral position in the group of Taras Nazarko studying mechanisms of lipophagy, the selective autophagy of lipid droplets (LDs). Lipophagy is accomplished by delivery of LDs from the cytosol to the lysosome (or vacuole in yeast). As in other autophagic pathways, the core autophagic machinery forms the autophagic isolation membrane that sequesters the LD from the cytosol. However, how this autophagic membrane recognizes the LD after lipophagy was induced is unknown. Also, it is not clear how lipophagy is kept in check the rest of the time. Therefore, lipophagy selectivity and regulation are the key gaps in our understanding of this pathway. A postdoctoral scholar will develop a project in one of these areas. Mechanistic understanding in these areas is critical for the precise control of lipophagy in humans for the prevention and treatment of various lipid accumulation diseases, like atherosclerosis and obesity. Initial appointment is for 1 year with possible extension for up to 5 years of overall postdoctoral training. Salary is commensurate with the Experience Level (http://postdoc.ucsd.edu/appointment-guidelines/)

Applicant Requirements:

The successful applicants will have a recent PhD in biochemistry, genetics, molecular or cell biology and a strong background in YEAST genetics, protein biochemistry and fluorescence microscopy. Expertise with mammalian cells or zebrafish model is a plus but not essential. Preference will be given to candidates with experience in AUTOPHAGY or LIPID DROPLETS.

How to apply:

Please send your cover letter, CV and contact information of 3 references to Taras Nazarko, tnazarko@ucsd.edu

Epigenetic Gene Regulation

Academic Division:

Biological Sciences

Academic Department/Research Unit:

Molecular Biology

Description:

We invite applications from highly motivated candidates for a postdoctoral position focused on elucidating molecular mechanisms of epigenetic gene regulation in cancer using a combination of biochemical, molecular, cellular, and genomic approaches. The candidate should have a strong interest in epigenetics, chromatin biology, and gene regulation. The candidate should also have experience in using biochemical and molecular biology techniques. Previous experience with system-wide data analysis is desirable but not necessary.

Projects in the lab are focused on the investigation of epigenetic mechanisms of transcriptional control, with a focus on chromatin-modifying factors, covalent posttranslational modifications of histone proteins, and noncoding RNAs in modulating gene expression networks regulated by wild-type p53 and the tumor-promoting p53 mutants in various mammalian biological contexts that include inflammatory responses, DNA damage, metabolism, and development.

Successful applicants should:

  1. Have a PhD and/or MD degree with research experience in biochemistry, molecular and cellular biology as evident by peer-reviewed publications in reputable journals.
  2. Be highly motivated, detail oriented, responsible individual with excellent communication and organizational skills
  3. Preference will be given to candidates with experience programming in R, Python, next generation sequencing analysis, or other bioinformatics techniques

How to apply:

Please email your cover letter, curriculum vitae, and the names and contact information of three references to Dr. Shannon Lauberth slauberth@ucsd.edu.

For more information, please visit the Lauberth Lab website.

Biochemical mechanisms and crosstalk of immune checkpoint receptors

Academic Division:

Biological Sciences

Academic Department/Research Unit:

Cell and Developmental Biology

Description:

Postdoctoral positions are available at Dr. Enfu Hui’s newly launched laboratory at the Division of Biological Sciences of University of California San Diego (UCSD). Dr. Hui has pioneered a novel membrane reconstitution system to understand the precise mechanisms of T cell activation (Hui & Vale, Nat. Struct. Mol. Biol., 2014) and suppression. He discovered that the T cell costimulatory receptor CD28 is a primary target of PD-1, an immune checkpoint receptor that can be hijacked by cancer for immune evasion.

The Hui Lab is interested in the biochemical mechanisms and crosstalk of additional immune checkpoint receptors, which are viable cancer immunotherapy targets with poorly defined molecular mechanisms. The successful candidates will investigate these fundamental questions using a combination of state-of-the-art membrane reconstitution, live cell single molecule imaging, cell biological, and synthetic biological techniques.

Successful applicants should:

  1. Have or expect a Ph.D. degree at the time of application.
  2. Prior experience with microscopy, protein chemistry, and signal transduction is preferred.

How to apply:

To apply, please send CV and contact information of three references to Dr. Enfu Hui enfuhui@ucsd.edu.

All positions are contingent on funding becoming available.

Applicants are welcome to include in their cover letters a personal statement summarizing leadership efforts and/or contributions to diversity. UC San Diego is an equal opportunity/affirmative action employer with a strong institutional commitment to the achievement of diversity among its faculty and staff.