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Postdoctoral Openings

Epigenetic Gene Regulation

Academic Division:

Biological Sciences

Academic Department/Research Unit:

Molecular Biology

Description:

We invite applications from highly motivated candidates for a postdoctoral position focused on elucidating molecular mechanisms of epigenetic gene regulation in cancer using a combination of biochemical, molecular, cellular, and genomic approaches. The candidate should have a strong interest in epigenetics, chromatin biology, and gene regulation. The candidate should also have experience in using biochemical and molecular biology techniques. Previous experience with system-wide data analysis is desirable but not necessary.

Projects in the lab are focused on the investigation of epigenetic mechanisms of transcriptional control, with a focus on chromatin-modifying factors, covalent posttranslational modifications of histone proteins, and noncoding RNAs in modulating gene expression networks regulated by wild-type p53 and the tumor-promoting p53 mutants in various mammalian biological contexts that include inflammatory responses, DNA damage, metabolism, and development.

Successful applicants should:

  1. Have a PhD and/or MD degree with research experience in biochemistry, molecular and cellular biology as evident by peer-reviewed publications in reputable journals.
  2. Be highly motivated, detail oriented, responsible individual with excellent communication and organizational skills
  3. Preference will be given to candidates with experience programming in R, Python, next generation sequencing analysis, or other bioinformatics techniques

How to apply:

Please email your cover letter, curriculum vitae, and the names and contact information of three references to Dr. Shannon Lauberth slauberth@ucsd.edu.

For more information, please visit the Lauberth Lab website.

Biochemical mechanisms and crosstalk of immune checkpoint receptors

Academic Division:

Biological Sciences

Academic Department/Research Unit:

Cell and Developmental Biology

Description:

Postdoctoral positions are available at Dr. Enfu Hui’s newly launched laboratory at the Division of Biological Sciences of University of California San Diego (UCSD). Dr. Hui has pioneered a novel membrane reconstitution system to understand the precise mechanisms of T cell activation (Hui & Vale, Nat. Struct. Mol. Biol., 2014) and suppression. He discovered that the T cell costimulatory receptor CD28 is a primary target of PD-1, an immune checkpoint receptor that can be hijacked by cancer for immune evasion.

The Hui Lab is interested in the biochemical mechanisms and crosstalk of additional immune checkpoint receptors, which are viable cancer immunotherapy targets with poorly defined molecular mechanisms. The successful candidates will investigate these fundamental questions using a combination of state-of-the-art membrane reconstitution, live cell single molecule imaging, cell biological, and synthetic biological techniques.

Successful applicants should:

  1. Have or expect a Ph.D. degree at the time of application.
  2. Prior experience with microscopy, protein chemistry, and signal transduction is preferred.

How to apply:

To apply, please send CV and contact information of three references to Dr. Enfu Hui enfuhui@ucsd.edu.

Autophagy of lipid droplets

Academic Division:

Biological Sciences

Academic Department/Research Unit:

Molecular Biology

Description:

Applications are invited for a postdoctoral position in the group of Taras Nazarko studying mechanisms of lipophagy, the selective autophagy of lipid droplets (LDs). Lipophagy is accomplished by delivery of LDs from the cytosol to the lysosome (or vacuole in yeast). As in other autophagic pathways, the core autophagic machinery forms the autophagic isolation membrane that sequesters the LD from the cytosol. However, how this autophagic membrane recognizes the LD after lipophagy induction is unknown. Also, it is not clear how lipophagy is kept in check the rest of the time. Therefore, lipophagy selectivity and regulation are the key gaps in our understanding of this pathway. A postdoctoral scholar will develop a project in one of these areas. Mechanistic understanding in these areas is critical for the precise control of lipophagy in humans for the prevention and treatment of various lipid accumulation diseases, like atherosclerosis and obesity. Initial appointment is for 1 year, with possible extension for up to 5 years of overall postdoctoral training. Salary is commensurate with experience (NIH NRSA scale).

Successful applicants should:

  1. Have a recent PhD in biochemistry, genetics, molecular or cell biology.
  2. A strong background in either YEAST or ZEBRAFISH genetics, protein biochemistry and fluorescence microscopy. Expertise with mammalian cells is a plus but not essential. Preference will be given to candidates with experience in AUTOPHAGY or LIPID DROPLETS.

How to apply:

Please send your CV, a brief (1-2 paragraphs) statement of research interests and contact information of 3 references to Taras Nazarko, tnazarko@ucsd.edu.

All positions are contingent on funding becoming available.

Applicants are welcome to include in their cover letters a personal statement summarizing leadership efforts and/or contributions to diversity. UC San Diego is an equal opportunity/affirmative action employer with a strong institutional commitment to the achievement of diversity among its faculty and staff.