A line of green balls colliding into red and orange balls with the fire symbol on them. There are two fire extinguishers on either side of the line of balls.

Quality Control Mechanisms inside Cells Help Clear Collisions

New model reveals ribosome serves as a unique signaling hub for quality control signals

Damaged or incorrectly processed mRNA can lead to the accumulation of deficient aggregation prone protein products that if not removed from the cell can have catastrophic consequences for an organism, including several neurological disorders including Parkinson's disease and amyotrophic lateral sclerosis (ALS). Understanding the quality control pathways and the molecular mechanisms involved in maintaining the health of cells is critical to better understanding and identifying potential therapeutic targets for when the system fails.