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Cornelis Murre

Research

The research in the Murre laboratory is focused on the regulation and function of helix-loop-helix proteins in stem cells, lymphocyte development and homeostasis. Control of tissue-specific gene expression during B and T lymphocyte development, cell growth, cell death and aging are prominent in our research. Additionally, our recent studies as a collaboration with the Supercomputer Center have resolved using high-precision fluorescence microscopy, computational tools and geometry, the 3D-structure of the immunoglobulin heavy chain locus.

Publications

  • Sayegh, C.E., Quong, M.E., Agata, Y. and Murre, C. 2003. E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nature Immunology 4:586-593.
  • Engel, I. and Murre, C. 2004. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J. 23:202-211.
  • Ikawa, T., Kawamoto, H., Wright, L.Y.T. and Murre, C. 2004. Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity 3:349-360.
  • Sayegh, C., Jhunjhunwala, S., Riblet, R. and Murre, C. 2005. Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells. Genes Devel. 19:322-327.
  • Schwartz, R., Engel, I., Fallahi-Schani, Petrie, H.T. and Murre, C. 2006. Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development. Proc. Natl. Acad. Sci. USA 103:9976-9981.
  • Agata, Y., Tamaki, N., Sakamoto, S., Ikawa, T., Masuda, K., Kawamoto, H. and Murre, C. 2007. Regulation of T cell receptor beta gene rearrangements and allelic exclusion. Immunity 27:871-884.
  • Jhunjhunwala, S., van Zelm, M.C., Peak, M., Cutchin, S., Riblet, R., van Dongen, J.J.M., Grosveld, F., Knoch, T.A. and Murre, C. 2008. The 3D-structure of the immunoglobulin heavy chain locus: Implications for long-range genomic interactions. Cell 133:265-279.