Dr. Zhang’s laboratory studies the molecular basis of cancer development, progression, and treatment. Her laboratory uses molecular biology, protein biochemistry, cell biology, and animal models to address questions related to blood cell differentiation, transformation, and innate immune responses. A major project underway in the Zhang laboratory focuses on the transcription factor AML1 (RUNX1) and its fusion protein AML1-ETO. As a second major project, Dr. Zhang studies the role of a ubiquitin-like modifier, ISG15, and the ISG15–specific protease, USP18 (UBP43), in interferon-initiated cell-signaling and cancer.
Dr. Dong-Er Zhang received her BS in Biochemistry at Peking (Beijing) University, China. She was selected to enter a graduate school in the United States through the CUSBEA (China-United States Biochemistry and Molecular Biology Examination and Administration) program and received her PhD in Biochemistry at the University of Houston. She was a Postdoctoral Scholar/Instructor at the University of Texas and then Instructor/Assistant Professor at the Harvard Medical School. In 1999, Dr. Zhang was recruited by The Scripps Research Institute as Associate Professor and was subsequently promoted to the Full Professor level before joining UCSD. Dr. Zhang was a Leukemia and Lymphoma Society Scholar (1998-2003) and received the prestigious Stolhman Scholar Award from the Leukemia and Lymphoma Society. She is involved in multiple international grant review committees and also contributes to the organization of scientific conferences.