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Randy Hampton


Our group studies a variety of questions that surround how the cell selectively destroys proteins. This work started with understanding how these sorts of mechanisms are employed to allow regulation of cellular cholesterol synthesis. These studies are ongoing and have led us in a number of interesting directions including cellular management of misfolded proteins, lipid signaling, and the dynamics of the ER and other organelles. For a complete picture of what we’ve done, what we do, and what we want to do, see the Hampton lab web site listed above. Thanks for stopping by!


  • Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, Bennett EJ. The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Mol Cell. (2015) 59:35-49.
  • Theesfeld CL, Hampton RY. Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.J Biol Chem. (2013) 288:8519-30.
  • Hampton RY, Sommer T. Finding the will and the way of ERAD substrate retrotranslocation. Curr Opin Cell Biol. (2012) 24:460-6.
  • Hampton RY, Lord JM, Roberts LM. Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p. Li S, Spooner RA, PLoS One. (2012) 7:e41119.
  • Theesfeld CL, Pourmand D, Davis T, Garza RM, Hampton RY.
  • The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.J Biol Chem. (2011) 286:26298-307.
  • Hampton RY. San1-mediated quality control: substrate recognition "sans" chaperones. Molecular Cell. (2011) 41:2-3.
  • Heck JW, Cheung SK, Hampton RY. Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1. Proc Natl Acad Sci U S A. (2010) 107:1106-11.
  • Carroll SM, Hampton RY. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. J Biol Chem. (2010) 285:5146-56.
  • Garza RM, Tran PN, Hampton RY. Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. J Biol Chem. (2009) 284:35368-80.
  • Sato BK, Schulz D, Do PH, Hampton RY. Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Molecular Cell. (2009) 34:212-22


Randy Hampton received his Ph. D. from the University of Wisconsin-Madison and did his postdoctoral work at UC Berkeley.