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Postdoctoral Openings

Postdoctoral Positions in the Oegema & Desai Labs

Description:

Postdoctoral research positions are available in the Oegema & Desai labs (ODLab) within the Division of Biological Sciences at UC San Diego. Research in the ODlab is focused on addressing mechanisms of cell division, with projects on chromosome segregation/kinetochores, spindle assembly/centrosomes, and cytokinesis, as well as projects on control of mitotic entry, surveillance, and progression. The lab is also focused on relating fundamental understanding to the diversity of division mechanisms in different cell types/tissues and to pursue therapeutic targeting of cell division in cancer. Motivated candidates with prior research experience in mechanistic cell biology, microscopy (fixed and live imaging) and biochemistry/proteomics will be mentored to develop independent research projects. See oegemadesailab.org for more information.

Qualifications:

  • A Ph.D. in biology or related field; a Ph.D. in chemistry, physics or engineering will be considered with proper justification
  • No more than 2 years of previous postdoctoral research (i.e. within two years of doctoral degree conferment)
  • Experience with standard and emerging molecular biology approaches, microscopy, and biochemistry; experience with genome editing and cell engineering is desired but not required
  • Strong oral communication skills are required

Research Environment:

The ODlab is part of the large and highly collaborative Division of Biological Sciences and the Department of Cellular and Molecular Medicine at UC San Diego. Successful applicants will join a dynamic research environment to lead an independent project related to cell division and cancer. Postdocs in the ODlab lab are also encouraged to participate in collaborative projects to both enhance their knowledgebase and expand their scientific network.

How to Apply:

Please email odlabjobs@gmail.com to apply.

Email applications should include:

  • Cover letter summarizing previous research experience
  • Brief (<1 page) description of potential project interests and career goals
  • CV with complete publication list
  • Contact information for 3 referees

Postdoc in Neural Evolution and Development

Academic Division:

Biological Sciences

Academic Division/Research Unit:

Cell & Developmental Biology

Description:

We seek an outstanding postdoctoral candidate to join the Perry lab at the University of California, San Diego. Our group uses genetic and genomic approaches to study the development and evolution of neural systems. We use the insect visual system as a model to understand how the genome encodes the complexity of the brain and nervous system. We are interested in the mechanisms that generate the exquisite diversity of ways in which animals perceive and interact with the world.

We are seeking independent, passionate, and highly motivated applicants for a postdoctoral position to study the  evolution and development of butterfly color vision . Butterflies have more complex retinal mosaics, allowing for an increased number of color comparisons (see Perry et al. Nature 2016). A successful applicant will use CRISPR to test candidate gene function directly in developing butterfly retinas. We are interested in understanding how the brain interprets additional input and the role of developmental plasticity. This approach will, in part, use genetic tools in  Drosophila to understand relevant circuits. The lab also uses single cell sequencing (10x Genomics) to uncover differences in neural systems across species followed tests of candidate gene function.

Applicant Requirements:

A Ph.D. in the biological sciences that includes at least three years of laboratory research experience in molecular or developmental biology is required. Experience with Drosophila or other genetic model systems is preferred but not required.

How to Apply:

This is a renewable two-year position with full benefits, which will be extended as needed upon performance of the candidate. Salary will be competitive and dependent on the level of experience. Applicants should email a CV and a description of research interests to Prof. Perry (mwperry@ucsd.edu), along with contact information for three references. Applications submitted by July 15th, 2021 will receive priority consideration, but the position will remain open until filled. Start date is flexible.

It is an incredibly exciting time to be a developmental biologist as new tools such as CRISPR and single cell sequencing allow us to move beyond model systems in order to ask targeted questions about the mechanisms that adapt animals to their unique environments. Apply and join the adventure!

Two fully-funded postdoctoral positions

Academic Division:

Biological Sciences

Academic Department:

Molecular Biology

Description:

Two fully-funded postdoctoral positions are available in the laboratory of Dr. Maho Niwa in the Section of Molecular Biology at the University of California San Diego. The projects is interested in how eukaryotic cells handle non-genomic stress: (1) Specifically, how the Endoplasmic Reticulum (ER) responds to cellular stress such as increased demands for secretory protein or lipid production brought on by environmental challenge, injury or disease. This project focuses on the multi-dimensional Unfolded Protein Response (UPR) signaling pathway in normal and disease states. (2) Separately, we discovered and are focused on understanding the first cell cycle checkpoint that monitors the ER, termed the ER Surveillance Checkpoint (ERSU). The ERSU checkpoint ensures that the size and functional capacities of the ER expand to meet the challenge of supplying two dividing cells during the cell cycle. We have shown, for example, that stress activation of this cell cycle checkpoint (which is independent of the UPR) causes a halt in cytokinesis by negatively regulating the septin complex needed to physically separate mother from daughter cells in S. cerevisiae mitosis. We are investigating how ER stress pauses this cell cycle progression machinery, using molecular and cellular approaches in both yeast and mammalian models. (3) We further study inter-organellar communication between the ER and the cell nucleus, in a new project funded by an Allen Distinguished Investigator Grant geared to understanding the architectural and functional coordination between these vital organelles and how they change under stress. This is critically important in mammalian cells as the ER and nuclear membranes are contiguous at multiple contact points and, at the onset of mitosis, the nuclear envelope (NE) breaks down and all the integral nuclear membrane proteins move into the ER. Later, as nuclear membranes reform at the end of mitosis, the integral nuclear membrane proteins must be preferentially retrieved from the ER. Overall, failure of the ER to meet one or more of the challenges detailed above is an underlying cause of many human diseases, including cancers and neurodegenerative disease. Therefore, we also use normal and disease models to dissect how the failure of the ER to make the needed changes in response to different stressors leads to human disease.

Applicants:

  • Applicants should have a Ph.D. degree in molecular biology or a related field.
  • Applicants should send the following information to mniwarosen@ucsd.edu
    • CV
    • Cover Letter summarizing how your expertise and interests fit with the lab projects
    • Contact information of 3 professional references

For additional information please visit the Niwa Lab Website

Proteostasis regulation in health and disease

Academic Division:

Biological Sciences

Academic Department:

Cell & Development Biology

Description:

A postdoctoral research position is available in the Bennett lab within the Division of Biological Sciences at UCSD. Research in the Bennett lab utilizes integrative molecular, cellular, and proteomic approaches to both identify new factors within stress response and protein quality control pathways, and to manipulate these pathways to alter stress response outcomes. Our goal is to leverage our molecular understanding of these pathways to beneficially impact aging-associated disorders. The Bennett lab is looking to recruit motivated postdoctoral researchers with strong previous research experience in biochemistry and/or cell biology. Initial research goals will focus on emerging projects centered on understanding the spatial organization of quality control pathways and investigating tissue-specific protein homeostasis networks. Postdocs are also encouraged to develop independent research projects. See ebennettlab.com for more information about the research environment.

Qualifications:

  • A Ph.D. in biology or related field.
  • No more than 2 years of previous postdoctoral research (i.e. within two years of doctoral degree conferment).
  • Experience with standard and emerging molecular biology approaches and cell engineering is desired but not required.
  • Existing knowledge of current proteomic technologies would be beneficial.
  • Strong oral communication skills are required.

Research Environment:

The Bennett lab is part of the large and highly collaborative Division of Biological Sciences at UCSD. Successful applicants will join a highly dynamic research group to serve as a project leader for an independent research project in the protein homeostasis research space. Postdocs in the Bennett lab also participate in collaborative research projects to both enhance their research knowledgebase and expand their scientific network.

How to apply:

Please email Eric Bennett at e1bennett@ucsd.edu to apply.

Email applications should include:

  • Cover letter summarizing previous research experiences.
  • CV with complete publication list.
  • Upon request, 3 letters of reference.

Viral populations and their interactions with cell intrinsic innate immunity

Academic Division:

Biological Sciences

Academic Department:

Molecular Biology

Description:

A post-doctoral position is available in the laboratory of Prof. Alistair Russell in the Division of Biological Sciences at the University of California, San Diego. Our group seeks to understand how complex, genetically variable, viral populations interact with cell intrinsic innate immunity. We seek to understand the role of standing variation in viral populations with the elicitation of an immune response, as well as understand the tolerance of variation within viral populations with respect to the same phenomenon. Our group possess expertise in influenza A virus, but will be seeking to explore other viral pathogens of broad human interest. Studies in our group employ methodologies including deep mutational scanning, high-throughput sequencing, and single-cell transcriptomics coupled to single-cell viral genomics. Initial appointment for one year, renewable thereafter.

Description of environment:

Russell lab is within the dynamic Biological Sciences department at UCSD, and postdoctoral trainees will have opportunities to both present at and attend seminars with other groups working on viral biology, immunology, and RNA biology. Our group resides within the newly-constructed Tata Hall and shares space with several other laboratories with which we have shared meetings. Our department at UCSD is highly collegial, with many opportunities for collaborations, both formal and informal. This is a mentored position, and it is expected that applicants will be seeking training in the foundational expertise of our group, as well as training and mentorship specific to their goals in career development.

What we’re looking for

  • PhD in biology or a related field
  • Experience in at least one of
    • Virology
    • Immunology
    • Molecular Biology
    • Computational Biology
  • It is NOT expected applicants will have experience in all of the above, we are looking for a candidate who may be seeking training in at least one of the above fields, and would love to receive enthusiastic candidates looking to change fields
  • Strong verbal and written communication skills

Application Materials:

  • CV
  • Cover letter including a paragraph describing how your research interests fit with the job described
  • Contact information for 3 references
  • Email to: a5russell@ucsd.edu

Glial Development and Neurodegenerative Diseases

Academic Division:

Biological Sciences

Academic Department:

Neurobiology

Description:

A post-doctoral position is available in the Division of Biological Science, Neurobiology section at UCSD in the laboratory of Stacey Glasgow. The primary goal of the research in the laboratory is to study how transcriptional and chromatin mechanisms regulate glial cell development and glioma tumor biology. We utilize biochemistry, molecular and cell biology, genetics, and chromatin conformation assays to address how developmental processes are reutilized during neurogenerative disease and malignancies.

Qualifications

Applicants must hold a Ph.D. or equivalent degree in biology, neuroscience or related fields. Candidates should have a strong background in molecular biology, animal models, and microscopy. Additional experience with developmental biology, cancer studies, and mouse surgery is desirable. The candidate will be expected to conduct an independent research project and work as part of a team.

How to Apply:

Please email Stacey Glasgow Ph.D. at sglasgow@ucsd.edu with any questions and to apply. Email applications should include:

  • A cover letter that summarizes past research and how your interests fit with the lab.
  • CV with complete publication list.
  • Contact information for 3 references

Mechanistic Dissection of Protein Disposal Machineries

Academic Division:

Biological Sciences

Academic Department:

Cell and Developmental Biology

Description:

A post-doctoral position is available in the newly-established laboratory of Prof. Sonya Neal at the Division of Biological Sciences of University of California San Diego (UCSD). We perform structural and biochemical analyses on cellular machineries involved in protein quality control through the ER-associated protein degradation (ERAD) pathway. ERAD is responsible for handling misfolded protein and protein assemblies to the cytosolic proteasome for degradation, a process that if impaired is strongly linked to neurodegenerative and protein misfolding diseases. We are using biochemistry, lipidomics, cell biology, and genetics to understand how rhomboid pseudoproteases remove multi-spanning membrane proteins from the ER lipid bilayer for targeted degradation by the cytosolic 26S proteasome. Studies will employ state-of-the-art tools for in vivo and in vitro manipulation of ERAD that has been developed by Dr. Neal (Molecular Cell, 2018).

What we offer:

  • A stimulating environment with freedom to develop new research directions
  • Regular opportunities to interact with our collaborators at UCSD Medical School, Salk, Scripps Research Institute, and the Sanford-Burnham Institute
  • Opportunity to participate in ER Stress Club held at the Sanford-Burnham Institute
  • Supportive mentorship for multi-faceted career development and opportunities tailored towards individual career goals
  • An NIH funded position at NRSA postdoctoral stipend levels+benefits
  • A department located in a metropolitan area of 1.3 million people with sunny weather, impressive beaches, variety of entertainment options and patchwork of diverse and vibrant neighborhoods

What we’re looking for:

  • Experience with structural biology and structural determination, as well as protein biochemistry, including protein production and purification is an asset
  • Collaborative, ambitious individuals with a strong interest in our research and environment
  • Ability to work independently to develop research projects and mentor others
  • Fearlessness in the design and implementation of new techniques and approaches for mechanistic analyses
  • Strong verbal and written communication skills

Application Materials:

  • CV
  • Cover letter including a paragraph describing how your research interests fit with the job described
  • Contact information for 3 references
  • Email to: seneal@ucsd.edu

Membrane Biology and Cellular Basis of Disease

Academic Division:

Biological Sciences

Academic Department/Research Unit:

Cell & Developmental Biology

Description:

Two NIH-funded postdoctoral positions are immediately available in the laboratory of Dr. Amy Kiger in the Section of Cell and Developmental Biology at the University of California San Diego. Projects will study cellular and molecular mechanisms of muscle T-tubule membrane organization and remodeling. Emphasis is on the underlying membrane trafficking and its genetic regulation involved in maintaining muscle function and the cellular basis in fly models of human myopathy.

Research opportunities build on our published and unpublished studies, including novel genetic screen results, in Drosophila muscles that address factors involved in shaping and remodeling T-tubule membranes critical for muscle function (see Ribeiro et al. 2011 PLoS Genetics; and Fujita et al. 2017 eLife). Specific efforts explore specific endocytic and autophagic mechanisms involved in regulated disassembly and reassembly of T-tubule membranes during developmental and adult muscle remodeling programs.

Qualifications:

  • Ph.D. degree in cell or developmental biology or a related field.
  • Expertise in at least several of these areas: membrane biology/trafficking, muscle biology, microscopy imaging and image analysis, tissue dissections, Drosophila genetics, molecular biology and/or biochemistry.
  • Beneficial familiarity with or strong interest in animal studies that combine modern genetic modification methods with advanced live cell microscopy imaging techniques.
  • Primary publications in peer-reviewed journals demonstrating research excellence.
  • Highly motivated to learn, explore, engage and communicate in their scientific pursuits.

Research Environment

The muscle membrane projects parallel additional ongoing Kiger lab research on the regulation of phosphoinositide functions, endolysosomal trafficking and autophagy in other fly tissues and human cells. Postdoctoral candidates broadly interested in these other areas of membrane biology research are also encouraged to apply.

Successful candidates will join a dynamic research environment within the UCSD Division of Biological Sciences, with access to many additional scientific and career/life opportunities in the broader San Diego research community.

How to apply:

Please email Amy Kiger Ph.D. at akiger@ucsd.edu with any questions and to apply. Email applications should include:

  • A cover letter that summarizes past research and how your interests fit with the lab projects.
  • CV with complete publication list.
  • Upon request, 3 letters of reference.

All positions are contingent on funding becoming available.

Applicants are welcome to include in their cover letters a personal statement summarizing leadership efforts and/or contributions to diversity. UC San Diego is an equal opportunity/affirmative action employer with a strong institutional commitment to the achievement of diversity among its faculty and staff.