Jeff Hasty


Dr. Hasty's research focuses on the construction and utilization of synthetic gene circuits for dissecting, analyzing, and controlling the dynamical interactions involved in gene regulation.

Select Publications

  • Tal Danino, Octavio Mondragón-Palomino, Lev Tsimring, Jeff Hasty (2010). A synchronized quorum of genetic clocks. Nature 426:326-330.
  • Natalie Cookson, Scott Cookson, Lev Tsimring, Jeff Hasty (2009). Cell cycle-dependent variations in protein concentration. Nucleic Acids Research 1-6.
  • Natalie Cookson, Lev Tsimring, Jeff Hasty (2009). The pedestrian watchmaker: Genetic clocks from engineered oscillators. FEBS Letters 583:3931–3937.
  • Matthew Bennett, Jeff Hasty (2009). Microfluidic devices for measuring gene network dynamics in single cells. Nature Reviews Genetics, 10:628-638.
  • Jesse Stricker, Scott Cookson, Matthew Bennett, William Mather, Lev Tsimring, Jeff Hasty (2008). A fast, robust and tunable synthetic gene oscillator. Nature 456:516-519.
  • Matthew Bennett, Wyming Lee Pang, Natalie Ostroff, Bridget Baumgartner, Sujata Nayak, Lev Tsimring, Jeff Hasty (2008). Metabolic gene regulation in a dynamically changing environment. Nature 454:1119-1122.


Jeff Hasty received his Ph.D. in Physics from the Georgia Institute of Technology in 1997, where he worked with Kurt Wiesenfeld. He was a postdoctoral fellow with Jorge Vinals at the Supercomputing Research Institute ('97-'98), and apostdoctoral fellow with Jim Collins in the Applied BioDynamics Lab at Boston University ('98-'01). Somewhereduring his postdoctoral stay at Boston University, he mutated into a hybrid computational/molecular biologist. He is currently at the University of California, San Diego, where he is a Professor in the Departmentsof Molecular Biology and Bioengineering, and the Director of the BioCircuits Institute. His main interest is thedesign and construction of synthetic gene-regulatory and signaling networks.